Savant Journal of Medicine and Medical Sciences (SJMMS)
November 2016 Vol. 2(9), pp. 177-183

Copyright © 2016 Savant Journals


Original Research Paper

Assessment of GammaGlutamyl Transferase and Lactate Dehydrogenase as Biochemical Markers of Preeclampsia Severity in Sudanese Pregnant Women’s in Khartoum State

Noon Babiker Mohammed1, Salih Ezzaldein Elias1

1Assistant Professor of Clinical Chemistry, University of Science and Technology, Sudan 2MSc in Clinical Chemistry, University of Science and Technology, Sudan.

*Corresponding Author E-mail: noonbabiker2012@hotmail.com

Accepted 1st November, 2016


Abstract

Preeclampsia is a pregnancy-specific disease with multisystem complications, it constantly associates with high blood pressure . There are very limited studies with conflicting data on GGT and LDH in preeclampsia. This study aimed to assess of Gamma Glutamyl Transferase and Lactate Dehydrogenase as Biochemical Markers of Severity of Preeclampsia in Sudanese pregnant women in Khartoum state and comparison with healthy normotensive pregnant controls. The glutamyl transferase and lactate de-hydrogenase was estimated in 100Sudanese pregnant women by spectrophotometer method. The mean values of plasma gamma glutamyl transferase in mild preeclamptic pregnant women were insignificant difference when compared to control Pvalue=0.346. The mean values of plasma gamma- glutamyltransferase in mild preeclamptic pregnant women were the insignificant difference when compared to control P value=0.089. The mean values of plasma lactate dehydrogenase in mild preeclamptic pregnant women were significant increase when compared to control Pvalue =0.008. The mean values of plasma lactate dehydrogenase in severe preeclamptic pregnant women were significant increase when compared to control P value =0.001. Result showed significant positive moderate correlation between lactate dehydrogenase and diastolic blood pressure in sever preeclampsia(p value = 0.006 and r = .851) and significant positive moderate correlation between lactate dehydrogenase and diastolic blood pressure in mild preeclampsia (p value = 0.013 and r = .782) and insignificant correlation between gamma glutamyltransferase and diastolic blood pressure in sever preeclampsia (p value = 0.359 and r = .215) and insignificant correlation between gamma glutamyltransferase and diastolic blood pressure in mild preeclampsia(p value = 0.652 and r = - .189). From the result of this study, it is concluded that: levels of LDH is raised in Sudanese pregnant women with hypertensive preeclampsia and level of GGT level normal in Sudanese pregnant women with hypertensive preeclampsia.And showed a significant positive moderate correlation between lactate dehydrogenase and diastolic blood pressure in Sudanese pregnant women with hypertensive preeclampsia diseaseand disease and showed an insignificant correlation between gamma-glutamyltransferase and diastolic blood pressure in Sudanese pregnant women with hypertensive preeclampsia disease.

Keywords: Gamma GlutamylTransferase, Lactate Dehydrogenase, normotensive, Preeclampsia.